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. 2016 Oct 10;113(43):12150–12155. doi: 10.1073/pnas.1613055113

Fig. 1.

Fig. 1.

The binding site of CHL and LZD in the peptidyl transferase center of the 50S ribosomal subunit. (Top) The chemical structures of CHL and LZD. (Bottom) When bound to the large ribosomal subunit in the PTC A site, the molecules of CHL (orange) and LZD (blue) would sterically clash with the aminoacyl moiety of the aminoacyl-tRNA (yellow). P-site–bound peptidyl-tRNA esterified with the nascent peptide chain is purple. The images were prepared based on the structures with the Protein Data Bank ID codes 4V7T, 3DLL, and 3J5L (10, 20, 46).