Fig. 6.

Impact of $K_S$ on SELEX dynamics. The plot shows the evolution of $K_D$ distribution for three different values of $K_S$. Similar to target concentration, we find an optimal outcome in the middle range ($K_S={10}^{-12}M$, blue), but the outcome for low $K_S$ is not as adverse as for low $T^{tot}$, because the distribution still shifts toward low $K_D$ with increasing cycles.