Fig. S1.

Expression analysis of viral envelope glycoproteins and promoters. (A–L) Different glycoproteins and promoters were trialed with lentiviral vectors and their biodistribution was examined 3 wk poststereotaxic delivery in the frontal cortex and HIP of wild-type mice. Expression was confirmed in several brain areas both proximal and distal to the injection sites (n = 3, 16–20 sections). (Scale bars: 250 μm.) (M) HEK293T cells were transfected with the transfer genome plasmid for CMV-eGFP, CMV-hPGC-1α, and SYN-hPGC-1α, respectively. Representative Western blots of cell lysates for the V5 tag of hPGC-1α, hPGC-1α, and β-actin as loading control.