Fig. S4.
Neuronal cell density in subiculum of animals injected with LV-hPGC-1α or LV-eGFP. (A–D) Representative images of the subiculum where no changes were detected between LV-eGFP– (A, wild-type; C, APP23) and LV-hPGC-1α–injected mice (B, wild-type; D, APP23). (Scale bars: 0.1 mm.) (n = 3 for wild-type and n = 5 for APP23, six sections per mouse). (E) Quantification of NeuN+ cells in the subiculum of APP23 mice injected with LV-eGFP or LV-hPGC-1α showed no significant differences in the neuronal numbers (n = 5, six sections per mouse, two-tailed Student’s t test). (F) Western blot for PSD-95 in wild-type mice showed no changes between wt/LV-eGFP and wt/LV-hPGC-1α (two-tailed Student’s t test, n = 4).