Table 2.
Gene | Cancer gene annotation | Coding size | No. nonsilent | No. silent | No. conserved missense | No. damaging | q |
KRAS | Oncogene | 574 | 5 | 0 | 4 | 1 | 0 |
PTEN | TSG | 1,221 | 10 | 0 | 4 | 6 | 0 |
TP53 | TSG | 1,192 | 31 | 0 | 12 | 11 | 0 |
PIK3CA | Oncogene | 3,227 | 11 | 0 | 11 | 0 | 0 |
PIK3R1 | TSG | 2,190 | 4 | 0 | 0 | 4 | 0 |
PPP2R1A | Oncogene | 1,785 | 5 | 0 | 5 | 0 | 7.81 × 10−3 |
RB1 | TSG | 2,814 | 2 | 0 | 0 | 2 | 7.04 × 10−2 |
HIST1H2BJ | Unknown | 382 | 2 | 0 | 2 | 0 | 9.38 × 10−2 |
HIST1H2BG | Unknown | 382 | 2 | 0 | 1 | 1 | 1.89 × 10−1 |
FBXW7 | TSG | 2,135 | 3 | 0 | 3 | 0 | 1.89 × 10−1 |
The “Cancer gene annotation” column indicates the role of the gene in carcinogenesis, either as an oncogene or tumor suppressor gene (TSG) (26) or unknown. The “q” column shows the q values returned by MutSigCV.