Table 2. Details of somatic mutations in EGFR, BRAF and KRAS genes analyzed in this study.
| Gene | Mutation | Exon | Base Change |
|---|---|---|---|
| EGFR | |||
| G719A | 18 | 2156G > C | |
| G719S | 18 | 2155G > A | |
| G719C | 18 | 2155G > T | |
| E746_A750del (1) | 19 | 2235_2249del15 | |
| E746_A750del (2) | 19 | 2236_2250del15 | |
| L747_P753 > S | 19 | 2240_2257del18 | |
| E746_T751 > I | 19 | 2235_2252 > AAT(complex) | |
| E746_T751del | 19 | 2236_2253del18 | |
| E746_T751 > A | 19 | 2237_2251del15 | |
| E746_S752 > A | 19 | 2237_2254del18 | |
| E746_S752 > V | 19 | 2237_2250 > T(complex) | |
| E746_S752 > D | 19 | 2238_2255del18 | |
| L747_A750 > P | 19 | 2238_2248 > GC(complex) | |
| L747_T751 > Q | 19 | 2238_2252 > GCA(complex) | |
| L747_E749del | 19 | 2239_2247del9 | |
| L747_T751del | 19 | 2239_2253del15 | |
| L747_S752del | 19 | 2239_2256del18 | |
| L747_A750 > P | 19 | 2239_2248TTAAGAGAAG > C (complex) | |
| L747_P753 > Q | 19 | 2239_2258 > CA (complex) | |
| L747_T751 > S | 19 | 2240_2251del12 | |
| L747_T751del | 19 | 2240_2254del15 | |
| L747_T751 > P | 19 | 2239_2251 > C (complex) | |
| T790M | 20 | 2369C > T | |
| S768I | 20 | 2303G > T | |
| H773_V774insH | 20 | 2319_2320insCAC | |
| D770_N771insG | 20 | 2310_2311insGGT | |
| V769_D770insASV | 20 | 2307_2308insgccagcgtg | |
| L858R | 21 | 2573T > G | |
| L861Q | 21 | 2582T > A | |
| KRAS | |||
| Gly12Asp | GGT > GA T | ||
| Gly12Ala | GGT > GCT | ||
| Gly12Val | GGT > GTT | ||
| Gly12Ser | GGT > AGT | ||
| Gly12Arg | GGT > CGT | ||
| Gly12Cys | GGT > TGT | ||
| Gly13Asp | GGC > GAC | ||
| BRAF | |||
| V600E | 15 | 1799T > A | |