Table 1.
Detailed demographics, clinical, and medication information of the study population.
| Bipolar-Manic Subjects (n=28) | Bipolar- Euthymic Subjects (n=24) | Healthy Control Subjects (n=23) | Statistic | |||
|---|---|---|---|---|---|---|
| Demographics | Control vs Mania | Mania vs Euthymia | Euthymia vs Control | |||
| Age in years, mean (SD) | 27.5 (10.7) | 30.9 (11.9) | 29.7 (10.9) | MW p=.174 | MW p=.060 | MW p=.840 |
| Sex | df=1 χ2=.021 p=.884 | df=1 χ2=.138 p=.711 | df=1 χ2=.045 p=.831 | |||
| male | 20 | 16 | 16 | |||
| female | 8 | 8 | 7 | |||
| Clinical Characteristics | ||||||
| YMRS, mean (SD) | 25.8 (7.28) | 2.33 (3.40) | n/a | MW p<.001 | ||
| MADRS, mean (SD) | 12.0 (6.41) | 5.33 (5.46) | n/a | MW p<.001 | ||
| PANSS, mean (SD) | 59.0 (10.9) | 38.6 (8.11) | n/a | MW p<.001 | ||
| PANSS positive subscale, mean (SD) | 22.2 (5.60) | 9.33 (4.24) | n/a | MW p<.001 | ||
| Anticonvulsants | 11/28 | 9/24 | n/a | df=1 χ2= .017 p=.895 | ||
| Antipsychotics | 27/28 | 15/24 | n/a | df=1 χ2=9.58 p=.002 | ||
| CPZ equivalents, mean (SD) | 368 (252) | 143 (200) | n/a | MW p<0.001 | ||
| Benzodiazepines | 8/28 | 4/24 | n/a | df=1 χ2=1.03 p=.310 | ||
| Lithium | 21/28 | 16/24 | n/a | df=1 χ2= .437 p=.508 | ||
| Antidepressants | 0/28 | 1/24 | n/a | df=1 χ2=1.19 p=.275 | ||
| framewise displacement in mm, mean (SD) | .149 (.074) | .133 (.051) | .121 (.071) | t(81) = 1.78 p=.078 | t(79)= .587 p=.559 | t(84) = 1.47 p=.152 |
Abbreviations: MW Mann-Whitney U Test, PANSS: Positive And Negative Symptom Scale, SD: Standard Deviation, YMRS: Young Mania Rating Scale.