Table 3.

ROIs demonstrating significant differences in whole-brain connectivity between groups.

Seed Region		Change in Functional Connectivity	Area	Coordinates	T-stat	Cluster size (voxels)	Cluster size p-value
Bilateral amygdala
	mania v euthymia
		Increased in mania	left SMA	x-36 y-9 z54	4.82	46	<.001
			right SMA	x18 y3 z63	4.79	73	<.001
			right BA5	x21 y-48 z69	3.83	51	<.001
		Increased in euthymia	ACC	x0 y39 z6	5.41	180	<.001
	mania v HC
		Increased in mania	left CBM	x-45 y-54 z-39	5.24	44	<.001
	euthymia v HC
		Increased in HC	right BA5	x18 y-48 z69	5.12	105	<.001
			left SMA	x-33 y-9 z57	4.22	42	<.001
			right SMA	x48 y-6 z48	4.14	79	<.001
			left BA5	x-21 y-48 z66	3.9	43	<.001
ACC
	mania v euthymia
		Increased in euthymia	right amygdala	x18 y-3 z-21	5.32	38	<.001
left VLPFC
	mania v euthymia
		Increased in euthymia	right CBM	x33 y-69 z-18	4.34	36	<.001
OFC
	mania v euthymia
		Increased in mania	CBM (midline)	x3 y-60 z-21	4.04	52	<.001
		Increased in euthymia	left BA18	x-3 y-96 z-21	5.03	35	<.001
	mania v HC
		Increased in mania	CBM (midline)	x12 y-60 z-24	4.99	104	<.001
R Amygdala
	mania v euthymia
		Increased in mania	left SMA	x-36 y-9 z54	4.32	35	<.001
			right SMA	x27 y-6 z51	4.3	46	<.001
		Increased in euthymia	ACC	x0 y39 z6	5.87	187	<.001
	mania v HC
		Increased in mania	left CBM	x-45 y-54 z-39	5.04	44	<.001
	euthymia v HC
		Increased in HC	right BA5	x18 y-45 z72	4.7	59	<.001
			right SMA	x36 y-9 z45	4.16	63	<.001
L amygdala
	mania v euthymia
		Increased in euthymia	ACC	x-3 y45 z9	4.27	59	<.001

Coordinates are in MNI (Montreal Neurological Institute) space.

Abbreviations: ACC Anterior Cingulate Cortex, BA: Brodmann Area, CBM: Cerebellum, DLPFC: Dorsolateral Prefrontal Cortex, ITG: Inferior Temporal Gyrus, MTG: Medial Temporal Gyrus, OFC: Orbitofrontal Cortex, R: Right, SMA: Supplemental Motor Area, VLPFC: Ventro-Lateral Prefrontal Cortex