Fig. 4. Bacterial dynamics correlate with several diseases and metabolic disorders.
Peak-to-trough ratios (PTR) of species from Chinese (7; N=363; Q) and European (9; N=396; M) cohorts are shown (boxplots, left; red-median; boundaries-25–75th percentiles) if its relative abundances or PTRs were significantly associated with clinical parameters. Shown are phylum membership; the number of samples for which PTRs were calculated; and a row with colored entries for each statistically significant (FDR-corrected p<0.05) association between clinical parameters and its PTR (left column block) or relative abundance (right column block). Mann-Whitney U-test and Spearman correlations were used for binary and continuous clinical parameters, respectively. Top-block: species with significant associations between PTR and clinical parameters; bottom-block: species with significant associations only between relative abundance and clinical parameters. A-Actinobacteria, B-Bacteroidetes, E- Euryarchaeota. F-Firmicutes, P-Proteobacteria, V-Verrucomicrobia