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. Author manuscript; available in PMC: 2016 Oct 31.
Published in final edited form as: ACS Chem Biol. 2016 Mar 30;11(6):1552–1560. doi: 10.1021/acschembio.6b00083

Figure 6.

Figure 6

Models for small-molecule control of complex stability. a) ADEP binding to an empty ClpP cleft allosterically stabilizes a conformation from which ClpX rapidly dissociates. For simplicity, only a subset of IGF loops in ClpX and clefts in each ring of ClpP are shown. b) ADEP binding to a ClpP cleft transiently unoccupied by an IGF loop prevents re-docking and stimulates dissociation. c) ATP binding to the ClpX hexamer stabilizes a conformation of the IGF loops that binds the ClpP clefts more efficiently. d) ATP binding to the ClpX hexamer positions the IGF loops to interact optimally with ClpP.