Table 2.

Univariate and multivariate analyses of factors associated with survival and recurrence.

				OS				DFS
				Univariate	Multivariate			Univariate	Multivariate
Variables				p value	HR	95% CI	p value	p value	HR	95% CI	P value
Age, years	>50	vs.	≤50	0.735			NA	0.899			NA
Gender	female	vs.	male	0.612			NA	0.711			NA
HBeAg	positive	vs.	negative	0.085			NA	0.554			NA
Liver cirrhosis	present	vs.	absent	0.819			NA	0.838			NA
ALT, U/L	>45	vs.	≤45	0.488			NA	0.577			NA
AFP, ng/mL	>25	vs.	≤25	0.117			NA	0.159			NA
Tumor size, cm	>5	vs.	≤5	<0.001			NS	0.001			NS
Tumor multiplicity	multiple	vs.	solitary	0.061			NA	0.082			NA
Vascular invasion	present	vs.	absent	0.002	2.231	1.183–3.244	0.014	0.004	2.358	1.154–3.652	0.002
Intrahepatic metastasis	yes	vs.	no	<0.001			NS	<0.001			NS
TNM stage	III+IV	vs.	I+II	<0.001	0.389	0.201–0.574	0.002	<0.001	0.399	0.198–0.612	<0.001
Tumor differentiation	III+IV	vs.	I+II	0.077			NA	0.049			NS
Fibrous capsule	present	vs.	absent	0.778			NA	0.812			NA
Combine neutrophils and c-Met*				<0.001			NA	<0.001			NA

NOTE: Cox proportional hazards regression model. *Patients were classified into four groups according to their peritumoral neutrophil density and tumor c-Met expression.

Abbreviations: HR, hazard ratio; OS, overall survival; CI, confidence interval; DFS, disease-free survival; AFP, α-fetoprotein; NA, not adopted; NS, not significant.