Table 2.

Univariate and multivariate Cox Proportional Hazard analyses on biochemical recurrence-free survival in a cohort of prostate cancer cases treated by radical prostatectomy—TCGA cohort.

	Univariate			Multivariate (n = 350)
Variable	n	p	Hazard Ratio [95% CI]	p	Hazard Ratio [95% CI]
pT3–4 vs. pT1–2	404	< 0.001	5.37 [2.14–13.5]	0.013	1.67 [1.12–2.51]
pN1 vs. pN0	356	0.049	1.84 [1.00–3.35]	0.50	0.80 [0.41–1.54]
Gleason grade group (ISUP)	410	< 0.001	1.70 [1.34–2.13]	0.024	1.39 [1.04–1.85]
Preoperative PSA	408	< 0.001	1.04 [1.02–1.05]	0.16	1.02 [0.99–1.04]
R1 vs. R0	385	0.13	1.52 [0.89–2.61]
ERG-rearrangement	272	0.51	0.80 [0.41–1.57]
PD-1 methylation (dichotomized, cut-off 57.50%)	410	0.003	2.35 [1.35–4.10]	0.014	2.08 [1.16–3.74]
PD-1 methylation (dichotomized, median cut-off)	410	0.029	1.87 [1.07–3.30]
PD-1 methylation (continous variable)	410	0.021	1.03 [1.00–1.05]