Figure 1.

CD24 expression confers poor prognosis in oral cavity cancer. (A) Association of CD24 mRNA in squamous cell carcinoma of the oral cavity with regional lymph node metastasis. (N+, n = 10; N0, n = 7; p = 0.011). (B) Association of CD24 mRNA in nasopharyngeal carcinoma with the clinical stages (IIA, n = 16, IIB, n = 15; p = 0.019). (C) Impact of CD24 mRNA expression on overall survival of patients with oral cavity cancer patients (n = 52). Program X-tile was used to determine an optimal cut-off point for defining two groups of patients with different survival curves, based on relative CD24 mRNA expression. The vertical axis in panel A and B represents the normalized expression intensity of CD24 relative to the median intensity of all the probes in the microarray platform. Panels A and B were analyzed by two-tailed unpaired two-sample Student's t-test, error bars represent SEM. Panel C was analyzed by Kaplan-Meier analysis, and the log-rank test was used to determine whether the survival curves were significantly different; *p < 0.05.