. Author manuscript; available in PMC: 2016 Oct 31.

Published in final edited form as: J Am Chem Soc. 2015 Feb 24;137(9):3225–3228. doi: 10.1021/jacs.5b00613

Table 1.

Optimization of the Reaction Conditions



entry^a	substrate	ligand	yield (%)^b	ee (%)^c
1	1b	L1	72	87
2	1b	L2	69	92
3	1b	L3	62	40
4	1b	L4	54	83
5	1b	L5	63	91
6	1c	L2	74	92
7^d	1c	L5	75	95

Reaction conditions: (1) 5 mol % gold catalyst, 10 mol % AgSbF₆, 0.05 mmol substrate, 10 mg 4 Å molecular sieves, 1 mL CH₂Cl₂. (2) 5 mg PTSA·H₂O, 1 mL acetone, 0.1 mL H₂O.

Isolated yields after two steps.

ee was determined by chiral HPLC analysis of the crude product.¹⁶

0.1 mmol scale, c = 0.1 M, 20 min.