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. 2016 Sep 30;59(20):9390–9408. doi: 10.1021/acs.jmedchem.6b00948

Figure 4.

Figure 4

(A) X-ray structure of 23 bound to FimH (PDB 5F3F). Water-mediated H-bond of amide carbonyl to Y48. (B) Overlay of 23 with 24 (PDB 5F2F) and 1 (PBD 3MCY). Altered biphenyl ring conformation and amide carbonyl orientation of ortho-substituted mannosides 23 and 24 compared to 1.