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(A) X-ray
structure of 23 bound to FimH (PDB 5F3F). Water-mediated
H-bond of amide carbonyl to Y48. (B) Overlay of 23 with 24 (PDB 5F2F) and 1 (PBD 3MCY). Altered biphenyl ring conformation and amide carbonyl
orientation of ortho-substituted mannosides 23 and 24 compared to 1.