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. 2016 Sep 30;59(20):9390–9408. doi: 10.1021/acs.jmedchem.6b00948

Figure 5.

Figure 5

Computational docking models of isomeric C-mannosides: (A) S-hydroxy (21S) and (B) R-hydroxy (21R) bound to the FimH mannose-binding pocket. The accepted model of 21R is bound to FimH through water-mediated H-bond to D140 and N135.