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Pharmacodynamics of O-linked mannoside. Chronically infected mice were treated orally with 50 mg/kg of mannoside 24. Bladders were harvested at the designated time points following oral dosing and bacterial burden enumerated. Bars indicate geometric means. Differences between the designated time point and the 0 h time point were tested for significance using Mann–Whitney U test (* P < 0.05, ** P < 0.001).
