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. 2016 Oct 13;16(10):1699. doi: 10.3390/s16101699

Table 1.

Analytical performances of various methods for hCG detection.

Materials Methods Detection Limit Linear Range Reference
SPAAB-HRP/anti-hCG ELISA 0.012 mIU/mL - [3]
anti-hCG/ZnO PL 2 ng/mL 2–20 ng/mL [6]
anti-hCG/CdSe-ZnS QDs PL 0.5 mIU/mL - [7]
anti-hCG/AuNPs IGCA 5 ng/mL 10–600 ng/mL [5]
anti-hCG/gold film SPR <500 ng/mL - [8]
peptide aptamer LC 1 IU/mL 12.5–100 mIU/mL [2]
PF@SiO2-Ab2 and Fe3O4@PANI-Ab1 fluorescence 3 pg/mL 0.01–100 ng/mL [4]
peptide aptamer/AuNPs/4-nitrophenol colorimetry 15 mIU/mL 15–750 mIU/mL [26]
peptide aptamer/AuNPs colorimetry 25 mIU/mL 25–1000 mIU/mL [27]
anti-hCG/Au-MWCNTs/GS/GCE DPV 0.0026 mIU/mL 0.005–500 mIU/mL [13]
anti-hCG/AuE SWSV 15 pM 15–300 pM [10]
HRP-Ab2/hCG/Ab1/nafion/GCE CA 11.2 mIU/mL 200 mIU/mL [9]
anti-hCG/CS/graphene-SPE EIS 0.016 ng/mL 0.1–25 ng/mL [19]
anti-HCG/ FPD/GCE EIS 0.03 ng/mL 0.1–10 ng/mL [14]
anti-hCG/Pd@SBA-15/TH/HSO3-GS/GCE CV 8.60 pg/mL 0.01–16.00 ng/mL [20]
GCE/GS/NPG/anti-hCG CV 0.034 ng/mL 0.5–40.00 ng/mL [11]
hCG/HRP-anti-hCG/sol–gel/GE DPV 0.3 mIU/mL 0.5–50 mIU/mL [17]
Peptide aptamer/GO fluorescence 20 mIU/mL 0.05–20 IU/mL This work

SPAAB-HRP, horseradish peroxidase (HRP)-loaded nanospherical poly(acrylic acid) brushe (SPAAB); anti-hCG, human chorionic gonadotropin antibody; QDs, quantum dots; PF@SiO2, poly[(9,9-bis(3′-((N,Ndimethylamino)N-ethylammonium)propyl)-2,7-fluorene)-alt-2,7-(9,9-p-divinyl-benzene)-alt-fluorene)-alt-2,5-dimethyl-p-phenylenediamine] coated SiO2 nanoparticles; Fe3O4@PANI, polyaniline coated Fe3O4 nanoparticles; MWCNTs, multiwalled carbon nanotubes; CS, graphene sheets; GCE, glassy carbon electrode; AuE, gold electrode; Ab, antibody; SPE, screen printed electrode; FPD, 2-(4-Formylphenyl)[60]fulleropyrrolidine; HSO3-GS, Functionalized graphene nanomaterial with introduced -SO3 groups; SBA-15, one of mesoporous silicas with uniform tubular channels; TH, thionine; NPG, nanoporous gold; PL, photoluminescence; IGCA, immunogold chromatographic assay; LC, liquid crystal assay; DPV, differential pulse voltammetry; SWSV, square-wave stripping voltammetry; CA, chronoamperometry; EIS, electrochemical impedance spectroscopy.