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Follistatin treatment reduced renal injury and endothelial activation after IRI. Serum creatinine (A), and mRNA expression of KIM-1 (B), NGAL (C), and E-selectin (D) in kidney tissue at 3, 6 and 24 hours after renal IRI. Results expressed as mean ± SEM. * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001. White bar, sham (n = 6-8); lined bar, vehicle-treated (n = 7-9); black bar, FS-treated (n = 6-7).
