Table 3.

Composite Cardiovascular Disease, Congestive Heart Failure, Myocardial Infarction, and Stroke Associated With a 1000-mg Difference in Calibrated 24-Hour Urinary Sodium Excretion^a

Subgroups	Calibrated Urinary Sodium Excretion per 1000 mg/24 hb
	No.	HR (95% CI)	P Value	P Value for Interaction	No.	HR (95% CI)	P Value	P Value for Interaction
	Composite CVDc				Congestive Heart Failure
Overall	3528	1.10 (1.05–1.16)	<.001		3533	1.09 (1.02–1.15)	.005
Sex				.55				.55
Men	1946	1.12 (1.06–1.18)	<.001		1949	1.10 (1.03–1.18)	.006
Women	1582	1.09 (0.99–1.20)	.07		1584	1.07 (0.96–1.20)	.20
Race				.44				.23
Black	1460	1.14 (1.06–1.23)	<.001		1461	1.15 (1.05–1.26)	.003
Nonblack	2068	1.08 (1.02–1.16)	.02		2072	1.05 (0.97–1.14)	.23
Age, y				.14				.13
<60	1759	1.11 (1.04–1.19)	.001		1760	1.10 (1.02–1.19)	.02
≥60	1769	1.08 (1.00–1.16)	.04		1773	1.06 (0.97–1.15)	.20
Diabetes status				.52				.74
Diabetes	1674	1.11 (1.05–1.17)	<.001		1677	1.09 (1.02–1.16)	.01
No diabetes	1854	1.10 (1.00–1.21)	.06		1856	1.07 (0.94–1.21)	.33
History of CVD				.50				.29
CVD history	1135	1.12 (1.05–1.20)	<.001		1138	1.09 (1.01–1.18)	.02
No CVD history	2393	1.08 (1.00–1.17)	.05		2395	1.09 (0.99–1.19)	.08
	Myocardial Infarction				Stroke
Overall	3540	1.07 (0.98–1.16)	.11		3542	1.16 (1.05–1.28)	.003
Sex				.68				.97
Men	1951	1.06 (0.96–1.17)	.23		1950	1.15 (1.02–1.30)	.02
Women	1589	1.13 (0.96–1.34)	.14		1592	1.20 (0.98–1.47)	.08
Race				.30				.69
Black	1468	0.99 (0.85–1.15)	.88		1472	1.22 (1.05–1.42)	.01
Nonblack	2072	1.10 (0.99–1.21)	.07		2070	1.10 (0.94–1.29)	.24
Age, y				.66				.79
<60	1766	1.11 (0.98–1.25)	.10		1767	1.17 (1.02–1.34)	.03
≥60	1774	1.05 (0.93–1.18)	.42		1775	1.15 (0.98–1.34)	.09
Diabetes status				.64				.98
Diabetes	1682	1.08 (0.98–1.19)	.11		1684	1.17 (1.05–1.32)	.006
No diabetes	1858	1.03 (0.86–1.23)	.74		1858	1.13 (0.93–1.36)	.21
History of CVD				.74				.89
CVD history	1140	1.09 (0.98–1.21)	.10		1140	1.19 (1.05–1.35)	.005
No CVD history	2400	1.04 (0.90–1.21)	.59		2402	1.08 (0.91–1.29)	.38

Abbreviations: CVD, cardiovascular disease; HR, hazard ratio.

^aAdjusted for age, sex, race, clinic site, education, waist circumference, lean body mass index, body mass index, cigarette smoking, alcohol drinking, physical activity, low-density lipoprotein cholesterol, glucose, history of CVD, antidiabetic medications, lipid-lowering medications, diuretics, renin-angiotensin system blocking agents, other antihypertensive medications, urinary creatinine excretion, and baseline estimated glomerular filtration rate.

^bCalibrated to mean urinary creatinine excretion of 1569 mg/24 hours in men and 1130 mg/24 hours in women.

^cComposite CVD is defined as congestive heart failure, stroke, and myocardial infarction.