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. 2016 Oct 1;143(19):3470–3480. doi: 10.1242/dev.134098

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 6. — Clonal cell lineage tracing using Gaudí^LxBBW line confirms mode of cell division in the medaka intestine. (A) Experimental timeline. Double transgenic fish Hsp70::_nlsCRE were used. Temperature shift inducible Cre recombinase triggers stochastic shift in reporter colour and localization. The shift was triggered at larval stage (12 dpf) and intestines were analysed 90 dpi as indicated by green arrow. (B) Representation of multicolour Gaudí^LxBBW intestinal segment. Note that recombination in the tandem array of the LxBBW cassette results in multiple combinations of colours and localization, unambiguously barcoding each individual cell. (C). High-resolution MuVi-Spim visualization (false colour) of intestinal segment (532 µm) showing multi-colour labelling in the context of the organ.