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. 2016 Oct 15;143(20):3817–3825. doi: 10.1242/dev.138941

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© 2016. Published by The Company of Biologists Ltd

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Fig. 3. — Late and early expression of olfactory Cre drivers. (A) Strategy to generate the Gng8^cre allele. The position of the probe used for Southern blot is indicated. HA, homology arm; i, internal ribosome entry site (IRES). (B) Dorsal parts of the septal olfactory neuroepithelium of Gng8^+/cre;R26^+/flRFP, M71^+/cre; R26^+/flRFP or Omp^+/cre;R26^+/flRFP animals immunostained for RFP (red) and counterstained with DAPI (blue). A schematic coronal view of the turbinates is shown in the middle image, with a black square indicating the area where neurons were observed. sust., sustentacular; OSNs, olfactory sensory neurons. The most basally located RFP-positive neurons are indicated by cyan dots and correspond to the positions along the apicobasal axis indicated in C. Scale bar: 50 µm. (C) Positions of the most basal RFP-positive cells observed along the apicobasal axis (cyan dots, as illustrated in B) of the neuroepithelium of Gng8^+/cre;R26^+/flRFP mice (n=232 cells from two mice), M71^+/cre;R26^+/flRFP (n=264 cells from two mice) and Omp^+/cre;R26^+/flRFP (n=160 cells from two mice). Means and s.d. are indicated by thick and thin horizontal black lines, respectively. The gray shaded area represents the fifth percentile.