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Mek1DD expression rescues the tectal stem zone and inferior colliculus independently of the transcriptional regulation of the isthmic organizer genes in Ptpn11-cKO mutants. (A-I) In situ hybridization on sagittal sections of E12.5 brains of the indicated genotypes. Arrowheads indicate normal expression at the isthmus; arrows denote the restricted expression domains.
