Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model depicting the role of ERK in angiogenesis. In sprouting cells, Vegfa activates ERK through Plcg1, which leads to increased flt4 and dll4 expression. Subsequent activation of Flt4 by its ligand Vegfc promotes sprouting, while Dll4-mediated activation of Notch signaling in adjacent cells leads to reduction of ERK activation and reduced sprouting.
