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. 2016 Oct 15;143(20):3826–3838. doi: 10.1242/dev.137489

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Postnatal phenotypic analysis of Ctnnb1^GOFHTC mutants. (A) Representative images of humeri from P3 control and Ctnnb1^GOFHTC littermates stained with Alcian Blue/von Kossa or Alcian Blue. (B) MicroCT images of control and Ctnnb1^GOFHTC humeri (P28, frontal and lateral view). The lateral view reveals anterior-posterior differences in the trabecular density underneath the proximal growth plate in the mutant humerus. (C) Toluidine Blue/von Kossa-stained sections of control and Ctnnb1^GOFHTC P28 humeri. Orientation is proximal up and distal down. (D) Histomorphometric quantification of the bone volume (BV) to total volume (TV) ratio, trabecular thickness (Tb.Th), trabecular number (Tb.N) and trabecular spacing (Tb.Sp) of P28 proximal humeri comparing Ctnnb1^GOFHTC (n=8) and littermate controls (n=9). **P<0.01, ***P<0.001. Error bars indicate s.d. Genotype of control is Ctnnb1^ex3fl/+;Col10a1-Cre⁻.