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. 2016 Oct 15;143(20):3826–3838. doi: 10.1242/dev.137489

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — Partial reversal of the Ctnnb1^LOFHTC phenotype by conditional deletion of Rankl in HTCs. (A) Scatter plot showing the distribution (and mean) of the bone volume (BV) to total volume (TV) (%) of the different controls (n=17), Ctnnb1^LOFHTC (n=6), Ctnnb1^LOFHTC;Rankl^ΔHTC (Ctnnb1^l^acZ/fl;Rankl^fl/fl;Col10a1-Cre⁺) (n=8) and Rankl^ΔHTC (Rankl^fl/fl;Col10a1-Cre⁺) (n=8) specimens. *P<0.05, **P<0.01, ***P<0.001. (B-F) Representative images of sections through control, Ctnnb1^LOFHTC and ‘complete’ rescue Ctnnb1^LOFHTC;Rankl^ΔHTC humeri. (B) Alcian Blue/von Kossa staining. (C) Col1a1 ISH. (D) Osx immunohistochemical staining. (E) CD31 immunohistochemical staining. (F) Col10a1 ISH.