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. 2016 Oct 15;143(20):3826–3838. doi: 10.1242/dev.137489

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 7. — Alteration in chondrocyte-derived osteoblast and osteoclast numbers in P28 Ctnnb1^GOFHTC specimens. (A) Representative images of control and Ctnnb1^GOFHTC specimens below the chondro-osseous front at the proximal humeral growth plate. Immunofluorescent staining for Osx (red) and YFP (green), and DAPI staining for nuclei (blue). The dashed line indicates the position of the chondro-osseous border. (B) TRAP staining on control and Ctnnb1^GOFHTC littermates. Asterisks mark the osteoclasts at the chondro-osseous border. (C) The mean percentage of YFP⁺_(total) (which are progeny of Col10a1-Cre-expressing HTCs) and YFP⁺ Osx⁺ (the chondrocyte-derived osteogenic population) cells determined within the area 250 µm below the chondro-osseous front. (D) The mean number of osteoclasts lining the chondro-osseous front (marked by asterisks in B) in humerus and femur of control and Ctnnb1^GOFHTC specimens. Control is Col10a1-Cre⁺;Rosa^YFP/+; Ctnnb1^GOFHTC is Ctnnb1^ex3^fl/+;Col10a1-Cre⁺;Rosa^YFP/+. (C,D) **P<0.01, ***P<0.001. The number of samples analyzed (n) is indicated within the bars. Error bars indicate s.d.