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. 2016 Oct 15;129(20):3892–3902. doi: 10.1242/jcs.195685

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — The PDZ domain is dispensable for Wnt signal transduction to β-catenin. (A) Cartoon of DVL, with DIX and PDZ mutations indicated. (B,C) Graphs show SuperTOP assays in DVL TKO or control cells transiently (B) or stably (C) transfected with wt or mutant DVL2–GFP, with or without 6 h of incubation in WCM. Above, corresponding western blots. AP, treatment with alkaline phosphatase. (D) Graph shows SuperTOP assays of DVL TKO cells stably transfected with wt or ΔPDZ (Δ244–353) DVL2–GFP as in C. Error bars represent mean±s.e.m., n=3 independent experiments. Right panel, corresponding western blots.