Fig. 5.

Polθ expression positively correlates with HR but not MMEJ genes in solid tumours. (A) A Pearson’s test was used to compare POLQ mRNA expression and expression of any other analysed gene within each cohort. The number of patients analysed for lung, breast and colorectal cancer was 103, 221, and 52, respectively (Lemée et al., 2010; Pillaire et al., 2010; Allera-Moreau et al., 2012). A coefficient superior to 0.65 was considered associated to a positive correlation. Pathway enrichment analysis was performed using the KEGG pathway database. Pie charts report the pathways detected by KEGG analysis in relation to the number of genes in each pathway. (B) Venn diagram representing different correlating genes shared by the different tumour types. (C) Heatmap of the Pearson coefficients for correlation of expression between POLQ and genes involved in different DSB repair pathways. A white block is indicative of unavailable data. (D) Heatmap showing correlation between different genes involved in HR. A more intense colour indicates a stronger positive correlation.