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. 2016 Oct 25;9:6407–6415. doi: 10.2147/OTT.S111846

Figure 3.

Figure 3

Overexpression of HER2 in HER2-negative breast cell lines.

Notes: Overexpression of HER2 in MDA-MB-231 (A and C) and MDA-MB-468 (B and D) raised GPER1 in protein level (A and B) and mRNA level (C and D), following with elevation of GPER1 substrate CREB phosphorylation (A and B).

Abbreviations: CREB, cAMP response element-binding protein; GPER1, G protein-coupled estrogen receptor 1.