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The GMPR reaction. A, structures of substrates and cofactor. B, the proposed mechanism. C, partial reactions catalyzed by GMPR. D, the superimposed IN and OUT IMP and cofactor conformations as found in the x-ray crystal structure of E·IMP·NADPH (PDB entry 2C6Q). In the overlay, IMP from the OUT conformation is displayed as green lines, visible through the transparent magenta sticks of IMP from the IN conformation. This figure was rendered with UCSF Chimera (27).
