FIGURE 2.

Thrombin flux from clots growing on collagen/TF. A, dynamics of platelet aggregation (■) and fibrin formation (○) during CTI-treated (40 μg/ml) whole blood perfusion over collagen/high TF (1 molecule/μm²) at initial wall shear rate of 200 s⁻¹. B, measured TAT concentration and thrombin flux during blood perfusion over collagen/high TF in the presence (○) and absence (■) of GPRP. C, TAT concentration and thrombin flux for TF surface concentration from 1 molecule/μm² (■) to 0.1 molecule/μm² (○). D, averaged TAT concentration and thrombin flux from 13 healthy donors for blood perfusion (40 μg/ml CTI and 5 mm GPRP) over collagen/high TF at 200 s⁻¹. *, p < 0.05; **, p < 0.01.