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. 2016 Sep 7;291(44):23027–23035. doi: 10.1074/jbc.M116.754671

FIGURE 3.

FIGURE 3.

Thrombin flux is amplified after 500 s of clotting via thrombin feedback generation of FXIa. A, FXI antibody O1A6 disrupts thrombin feedback amplification loop by inhibiting FXIIa activation of FXI and blocking thrombin feedback activation of FXI. B, O1A6 (20 μg/ml, ○) abolished late stage increase in thrombin flux from growing thrombi during blood perfusion (40 μg/ml CTI, 5 mm GPRP) over collagen/high TF and caused significant reduction in final thrombin flux when compared with clotting without O1A6 (■). ***, p < 0.005.