Table 2.
In vitro release through dialysis membrane, ex vivo permeation, and ex vivo skin retention studies from LCG- and HPMC-based hydrogel
| Formulation codea | % Tr released across dialysis bagc | % Tr permeated through the skinc | % Tr accumulated into skinc |
|---|---|---|---|
| LCG | 9.93±0.21 | 3.22±0.34 | 12.25±0.40 |
| HPMC | 64.77±4.53 | 1.81±0.31 | 2.61±0.31 |
| Tr solutionb | 98.90±2.00 | – | – |
Notes:
a
All formulations are loaded with equivalent amount of Tr (1% w/w).
b
Tr solution in PG was enrolled in in vitro release study to prove its dialyzability.
c
The data of the drug released after 24 h were expressed as % mean ± SEM (n=3).
Abbreviations: FC, 38.46% lecithin, 46.16% capryol, and 15.38% water; HPMC, hydroxy propyl methyl cellulose; LCG, liquid crystalline nanogel; SEM, standard error of mean; Tr, terconazole.