Table 3.

In vivo skin deposition study representing amount of Tr deposited in the skin at various time intervals after single topical application of LCG- and HPMC-based hydrogel

Time (hour)	Formulationsa,b (μg deposited)
	LCG	HPMC gel
0.08c	72.1±1.9	30±0.8
2	67.1±2.8	24.8±2.8
4	63.1±1.8	18.4±8.0
6	24.4±5.8	17.4±2.0
24	20.5±1.5	7.7±3.9

Notes:

^aBoth the gels were loaded with equivalent amount of Tr (1% w/w).

^bThe data were expressed as mean ± SEM (n=4).

^c0.08 h is equivalent to 5 min.

Abbreviations: FC, 38.46% lecithin, 46.16% capryol, and 15.38% water; HPMC, hydroxy propyl methyl cellulose; LCG, liquid crystalline nanogel; SEM, standard error of mean; Tr, terconazole.