Table 1.
Common causes of rare subtypes of peripheral neuropathy
| Localization | Condition |
|---|---|
|
| |
| Diffuse, non-length dependent neuropathy | |
| Demyelinating sensory motor | AIDP |
| CIDP | |
| CIDP variants | |
| POEMS | |
| IgM anti-MAG neuropathy | |
| Waldenstrom's acroglobulinemia | |
| MGUS | |
| Diptheria | |
| Toxic exposures (hexane, arsenic, amiodarone) | |
| Demyelinating sensory | Sensory CIDP or AIDP |
| DADS (IgM anti-MAG neuropathy) | |
| Demyelinating motor | MMN |
| Axonal sensory motor | Toxic exposures |
| ASMAN | |
| AIP | |
| Axonal sensory | Paraneoplastic (Hu, CRMP-5, amphyphisin)69 |
| Sjögren's syndrome | |
| Chemotherapy (platinum based, bortezomib) | |
| Vitamin B6 toxicity | |
| Idiopathic | |
| HIV, HTLV | |
| Autoimmune hepatitis | |
| Celiac disease | |
| HSAN | |
| Friedrich's ataxia | |
| CANVAS | |
| SANDO | |
| CANOMAD | |
| Axonal motor | ALS |
| PMA | |
| Post-polio syndrome | |
| HIV, HTLV, WNV, Enterovirus D68 | |
| MMN without conduction block | |
| Radiation | |
| Monomelic amyotrophy | |
| HMN | |
| SMA (including Kennedy's syndrome) | |
| Complicated HSP | |
|
| |
| Multiple mononeuropathies | Systemic vasculitic neuropathy |
| Microscopic polyangiitis | |
| Wegener's granulomatosis | |
| Polyarteritis nodosa | |
| Churg-Strauss syndrome | |
| Cryoglobulinemia | |
| Sjögren's syndrome | |
| Rheumatoid arthritis | |
| SLE | |
| Non-systemic vasculitic neuropathy | |
| Neoplasm (malignant and benign) | |
| HNPP | |
| Sarcoidosis | |
| Amyloidosis | |
| MMN | |
| MADSAM | |
|
| |
| Polyradiculopathy | Compressive |
| Disc herniation/spondylosis | |
| Osteomyelitis | |
| Neoplasm | |
| Non-compressive | |
| Infection (CMV, VZV, Lyme, tuberculosis) | |
| Inflammatory (sarcoidosis) | |
| Neoplastic (leukemia, lymphoma) | |
| Radiation | |
|
| |
| Plexopathy | Compressive |
| Neoplasm | |
| Hemorrhage | |
| Non-compressive | |
| Infection (VZV, HSV, CMV, Lyme) | |
| Inflammatory (sarcoidosis) | |
| Neoplastic (leukemia, lymphoma) | |
| Radiation | |
|
| |
| Radiculoplexus neuropathy | Diabetic lumbar (diabetic amyotrophy) |
| Diabetic cervical | |
| Post-surgical inflammatory | |
| Non-diabetic lumbar or cervical | |
| Infection (VZV, HSV, CMV, Lyme) | |
| Inflammatory (sarcoidosis) | |
| Neoplastic (leukemia, lymphoma) | |
| Radiation | |
AIDP=acute inflammatory demyelinating polyneuropathy, CIDP= chronic inflammatory demyelinating polyneuropathy, POEMS=polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes, MGUS=monoclonal gammopathy of unclear significance, DADS=distal acquired demyelinating syndrome, MMN=multifocal motor neuropathy, ASMAN=acute sensory motor axonal neuropathy, AIP=acute intermittent porphyria, HIV=human immunodeficiency virus, HTLV=human T-lymphotrophic virus, HSAN=hereditary sensory autonomic neuropathy, CANVAS=cerebellar ataxia neuropathy vestibular areflexia syndrome, SANDO=sensory ataxia neuropathy dysarthria ophthalmoplegia, CANOMAD=chronic ataxic neuropathy, ophthalmoplegia, monoclonal IgM protein, cold agglutinins, disialosyl antibodies, ALS=amyotrophic lateral sclerosis, PMA=progressive muscular atropgy, WNV=West Nile virus, HMN=hereditary motor neuropathy, SMA=spinal muscular atrophy, HSP=hereditary spastic paraplegia, SLE=systemic lupus erythrematosus, HNPP=hereditary neuropathy with liability to pressure palsies, MADSAM=multifocal acquired demyelinating sensory and motor neuropathy, CMV=cytomegalovirus, VZV=varicella zoster virus, HSV=herpes simplex virus