Table 1.

Association of auto-antibodies with different SSc clinical phenotypes

Antibody Type	Prevalence %	Disease subtype	Clinical Phenotype
Anti-centromere	24–45	IcSSc	CREST Syndrome Pulmonary arterial hypertension
Anti-Scl-70	15–42	dcSSc	Rapidly Progressive SSc-ILD Cardiac Involvement
Anti-RNA polymerase III	5–31	dcSSc	Scleroderma Renal Crisis Tendon friction rubs, Joint contractures Myositis
Anti-U3RNP (Fibrillarin)	2–16	dcSSc	Scleroderma Renal Crisis Cardiac Involvement
Anti-PM-Scl	4–11	IcSSc	Myositis, arthritis, calcinosis Sicca syndrome SSc-ILD
Anti- Th/To	1–18	IcSSc	SSc-ILD Scleroderma Renal Crisis Gastrointestinal Involvement
Anti-U11/U12 RNP	3.2	-	SSc-ILD
Anti-U1-RNP	2–14	IcSSc	MCTD features
Anti-Ku	2	dcSSc	Myositis, arthritis, joint contractures
Anti-NOR 90	0.8–6	dSSc	SSc-ILD
Anti-Ro52	20–27	-	SSc-ILD

lcSSc: Limited cutaneous SSc.

dcSSc: Diffuse cutaneous SSc.

SSc-ILD: SSc-associated Interstitial Lung Disease.

MCTD: Mixed connective tissue disease.