Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Time to morbidity. F344-Tp53 rats were monitored daily and euthanized when signs of illness were identified: tumor presence, lethargy, dyspnea, abnormal mentation or a combination of the clinical signs. Homozygous rats had a median time to morbidity of 124 days (18 weeks), whereas heterozygous rats exhibited a median time to morbidity of 333 days (47 weeks) with a range of 115 to 438 days.
