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F344-Tp53 tumor phenotypes. Rats homozygous or heterozygous for the Tp53 mutation with outward signs of illness were euthanized and subjected to a full necropsy. Total numbers of tumors (n) identified in the 32 F344-Tp53 rats are shown. Some animals had multiple tumor types. Predominant tumor types in both Tp53−/− and Tp53+/− rats were osteosarcoma and meningeal sarcoma, with heterozygous animals exhibiting a wider spectrum of tumors.
