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. 2016 Oct 27;57(11):1995–2004. doi: 10.1194/jlr.M064956

Fig. 1.

Fig. 1.

Expression of genes for HUFA synthesis in liver (A), brain (B), and gastrocnemius muscle (C). A: In liver, CO diet with high LA/ALA ratio increased Fads2, Fads1, Elovl2, and Elovl5 mRNA in WT mice liver. HET showed elevated Fads-1 expression compared with WT. In HET mice, Fads2 mRNA was about half of that in WT. B: Except for decreased Fads2 expression in HET, no other dietary or genotype effect was found in brain. The expression of Elovl2 was an order of magnitude lower than other three genes. C: In gastrocnemius muscle, Fads2 in HET was about half in WT. Expression of Fads genes were much lower than in liver and brain. Black bars, WT; white bars, HET. Values were normalized with the housekeeping gene (Rpl7a) and expressed as relative to mean liver Fads2, which was set as 100. Mean ± SD, n = 6. Bars without same letter were significantly different, P < 0.05 by LSD multiple comparison. P values for the effect of diet, gene, and their interaction were calculated by two-way ANOVA.