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Oxidative modification of CL. Representation of L4CL oxidation by hydroxyl radicals (ROS) and subsequent production of α,β unsaturated lipid aldehydes as well as an CLox remnant. The head group of CL is drawn schematically to emphasize chemistry within the acyl chains. Unsaturated aldehydes lead to protein carbonylation, while CLox potentiates apoptosis, autophagy, or mitophagy leading to generalized mitochondrial dysfunction.
