Fig 3. The histone feedback loop and DNA coupled models differ in their response to the inhibition of DNA synthesis but not in their response to transcription blocks.

Shown variables and colour coding are as in Fig 2. In (A), inhibition of DNA replication was implemented by setting V₅ to 0 at 15000 s. In (B), inhibition of transcription was implemented by setting the transcription flux v₁ (see Fig 1) to 0.