Table 3. CYP2C19 genotype frequencies in the Orang Asli.
Genotype | Phenotype | Allele frequency (%) | ||||||
---|---|---|---|---|---|---|---|---|
Negritos | Senoi | Proto-Malays | All sub-tribes (n = 62) | |||||
Bateq (n = 9) | Kensiu (n = 10) | Lanoh (n = 10) | Che Wong (n = 13) | Semai (n = 14) | Kanaq (n = 6) | |||
*1/*1 | Normal metabolizer | 66.7 | 70.0 | 40.0 | 61.5 | 85.7 | 66.7 | 66.1 |
*1/*2 | Intermediate metabolizer | 0 | 10.0 | 30.0 | 0 | 14.3 | 0 | 9.7 |
*1/*3 | Intermediate metabolizer | 0 | 10.0 | 0 | 15.4 | 0 | 0 | 4.8 |
*1/*17 | Rapid metabolizer | 22.2 | 10.0 | 30.0 | 0 | 0 | 0 | 9.7 |
*1/*35 | Intermediate metabolizer | 11.1 | 0 | 0 | 0 | 0 | 33.3 | 4.8 |
*2/*3 | Poor metabolizer | 0 | 0 | 0 | 7.7 | 0 | 0 | 1.6 |
*3/*3 | Poor metabolizer | 0 | 0 | 0 | 15.4 | 0 | 0 | 3.2 |