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(A) Copy numbers of Methanobrevibacter smithii among patients with irritable bowel syndrome (IBS) and healthy controls (HC). (B) Copy numbers of M. smithii among patients with constipation-predominant IBS (IBS-C), diarrhea-predominant IBS (IBS-D), and HC. (C) Correlation between copy numbers of M. smithii and number of stools per week. p<0.05 was considered as significant. *Bonferroni corrected p-value.
