Table 2.

Univariate and Multivariate Analyses of Factors Associated with Overall Survival

	Univariate analysis		Multivariate analysis
	HR (95% CI)	p-value	HR (95% CI)	p-value
Periostin expression level (high vs low)	1.982 (1.111–3.536)	0.021*
MVI (yes vs no)	2.657 (1.488–4.741)	0.001*
PO×MVI†
0
1	4.126 (1.804–9.437)	0.001*	3.754 (1.621–8.693)	0.002*
2	5.597 (2.271–13.792)	<0.001*	4.833 (1.928–12.119)	0.001*
3	4.681 (1.971–11.118)	<0.001*	3.452 (1.424–8.366)	0.006*
Age, yr (>56 vs ≤56)	0.963 (0.529–1.753)	0.903
Sex (female vs male)	0.313 (0.124–0.793)	0.014*	0.390 (0.149–1.020)	0.055
Tumor size, cm (>5 vs ≤5)	2.025 (1.130–3.629)	0.018*
Tumor no. (multiple vs single)	1.572 (0.814–3.037)	0.178
Tumor stage (modified UICC)
I
II	5.818 (0.788–42.94)	0.084	5.939 (0.791–44.563)	0.083
III	13.44 (1.802–100.18)	0.011*	7.679 (1.003–58.815)	0.050
Presence of capsule (yes vs no)	1.081 (0.594–1.967)	0.800
AFP, ng/mL (>200 vs ≤200)	0.750 (0.388–1.449)	0.392

HR, hazard ratio; CI, confidence interval; MVI, microvascular invasion; PO, periostin; UICC, Union for International Cancer Control; AFP, α-fetoprotein.

^*p<0.05;

^†0: low PO×negative MVI; 1: high PO×negative MVI; 2: low PO×positive MVI; 3: high PO×positive MVI.