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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Int J Gynecol Pathol. 2016 Jul;35(4):289–300. doi: 10.1097/PGP.0000000000000243

Fig. 1. Distribution and spectrum of TP53 mutations in endometrial cancer.

Fig. 1

(A) Distribution and spectrum of TP53 mutations in endometrioid endometrial cancer (top) and serous endometrial cancer (bottom). Diagrams represent the protein domains of p53 encoded by TP53. The presence of a mutation is shown on the x-axis (‘lollipop’), the frequency of mutations is shown on the y-axis. Missense mutations are presented as green circles, truncating mutations (i.e. nonsense, frameshift, splice-site) are depicted in red circles, in-frame insertions and deletions are shown in black circles, and circles colored in purple indicate residues affected by different types of mutation at the same proportion. Plots were generated using cBioPortal (www.cBioPortal.org) and manually curated. Note that mutations affecting the hotspots R175, R248 and R273 are more frequent in serous than in endometrioid endometrial cancers. (B) Prevalence of ARID1A, PTEN, FBXW7 and PPP2R1A mutations in TP53-mutant endometrioid endometrial cancers (EECs; left), and prevalence of ARID1A, PTEN, FBXW7 and PPP2R1A mutations in TP53-mutant serous endometrial cancers (SECs; right). Mutation types/ color-codes as depicted in the legend. Plots were generated using cBioPortal (www.cBioPortal.org) and manually curated.