. Author manuscript; available in PMC: 2017 Jul 1.

Published in final edited form as: Int J Gynecol Pathol. 2016 Jul;35(4):289–300. doi: 10.1097/PGP.0000000000000243

Table 3.

Clinico-pathologic features, distribution of TP53 mutations and mutations in genes recurrently altered in endometrial cancers in TP53-mutant endometrial carcinomas classified according to integrative genomic subtypes.

		Total (n)	Integrative genomic subtype				p-value
		Total (n)	CN-high (n)	CN-low (n)	MSI (n)	POLE (n)	p-value
Tumor grade	Grade 1	2	0	0	0	2	<0.0001^*
	Grade 2	8	6	1	1	0
	Grade 3	54	46	0	4	4
Histologic type	Endometrioid	27	15	1	5	6	<0.0001^*
Histologic type	Serous	37	37	0	0	0	<0.0001^*
Type of TP53 mutation	Frameshift	7	6	0	0	1	0.1844^**
	Missense	49	41	1	5	2
	Nonsense	7	4	0	0	3
	Splice-site	1	1	0	0	0
Hotspot TP53 mutation	No	43	32	1	5	5	0.2545^*
Hotspot TP53 mutation	Yes	21	20	0	0	1	0.2545^*
Cases with multiple TP53 mutations	No	60	52	1	5	2	<0.0001^*
Cases with multiple TP53 mutations	Yes	4	0	0	0	4	<0.0001^*
ARID1A gene status	Wild-type	57	49	1	4	3	0.0140^*
ARID1A gene status	Mutant	7	3	0	1	3	0.0140^*
FBXW7 gene status	Wild-type	50	41	1	5	3	0.2631^*
FBXW7 gene status	Mutant	14	11	0	0	3	0.2631^*
PPP2R1A gene status	Wild-type	52	41	1	5	5	0.85549^*
PPP2R1A gene status	Mutant	12	11	0	0	1	0.85549^*
PTEN gene status	Wild-type	46	46	0	0	0	<0.0001^*
PTEN gene status	Mutant	18	6	1	5	6	<0.0001^*

Fisher’s exact test p-value;

^**

Chi-square test p-value.

CN-high, copy-number high (serous-like) integrative genomic subtype; CN-low, copy-number low (endometrioid) integrative genomic subtype; MSI, microsatellite instable (hypermutated) integrative genomic subtype; n, number of TP53-mutant cases; POLE, POLE (ultramutated) integrative genomic subtype. Hotspot TP53 mutations include R175, G245, R248, R249, R273 and R282.