Table 3.
Characteristics of human septin loci and disease associations
| Human Septin | Alternative Names | Human Chromosome Location | Expression | Disease Associations |
|---|---|---|---|---|
| SEPT1 | DIFF6 | 16p11.1 | Brain, Lymphocytes, Others | Alzheimer’s disease, Leukemia, Lymphoma |
| SEPT2 | NEDD5, DIFF6 | 2q37 | Brain, Lymphocytes, Others | Brain, Liver and Renal cancer, Von Hippel-Lindau syndrome, Alzheimer’s disease Shigella and Listeria infections |
| SEPT3 | SEP3, G-SEPTIN | 22q13.2 | Brain-specific | Brain cancer, Alzheimer’s disease |
| SEPT4 | ARTS, H5, PNUTL2, BRADEION, SEP4 | 17q22 | Brain, Testes, Eye, Lymphocytes | Alzheimer’s disease, Skin, Urogenital and Colon cancer, Leukemia, Male infertility (spermatogenesis defect) |
| SEPT5 | CDCREL-1, PNUTL1 | 22q11.21 | Brain, Eye, Platelets | Leukemia, Parkinson’s disease, Schizophrenia, Pancreatic Cancer |
| SEPT6 | SEP2, KIAA0128 | Xq24 | Ubiquitous | Schizophrenia, Leukemia, Hepatitis C |
| SEPT7 | CDC10 | 7q36.1 | Brain, Testes | Nervous system cancers, Male infertility (spermatogenesis defect) |
| SEPT8 | KIAA0202 | 5q31 | Brain, Retina and others | Retinal Degeneration |
| SEPT9 | MSF, PNUTL4 AF17Q25, OvBrSEPT, SINT1, KIAA0991 | 17q25 | Ubiquitous | Hereditary Neuralgic Amyotrophy, Leukemia, Breast, Ovarian and Colorectal cancers, Head and Neck cancers, classical Hodgkin lymphoma, Shigella and Listeria infections |
| SEPT10 | SEPT1-like | 2q13 | Ubiquitous | - |
| SEPT11 | FLJ10849 | 4q21.1 | Ubiquitous | Schizophrenia, Bipolar Disorder, Leukemia, Shigella and Listeria infections |
| SEPT12 | FLJ25410 | 16p13.3 | Lymphocytes, Testes | Male Infertility (spermatogenesis defect) |
| SEPT13 | - | 7p13 | Ubiquitous | - |
| SEPT14 | - | 7q11 | Testes | - |