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. Author manuscript; available in PMC: 2016 Oct 31.
Published in final edited form as: Cell Rep. 2016 Jul 14;16(4):1153–1165. doi: 10.1016/j.celrep.2016.06.061

Figure 4. Rewired hedgehog networks in tail and dorsal hair follicles.

Figure 4

Correlation networks for key Hedgehog, Wnt, and Hair Follicle genes in (c) dorsal and (d) tail skin. Lines connect significantly correlated gene pairs. (a–d) Mouse skin immunostained with an anti-SMO antibody (red) and counter-stained with DAPI (blue). SMO protein was present in (a) dorsal anagen follicles [(b) higher magnification of dashed box] and (c) tail follicles [(d) higher magnification] most prominently near the dermal papillae. Lower/Higher magnification scale bar indicate 500/200 µM. (e, f) (e) LGR5-EGFP dorsal telogen mouse skin and (f) tail skin immunostained with an anti-SMO antibody (red) and anti-EGFP antibody (green) and counter-stained with DAPI (blue). Scale bar is 50 µM, images taken at 40×. (g, h) Correlation networks for key Hedgehog, Wnt, and Hair Follicle genes in (g) dorsal and (h) tail skin, illustrating the tail skin-specific correlation between expression of Smo and expression of the Wnt and Hair Follicle networks. Lines connect significantly correlated gene pairs.