Table. Clinical characteristics of probable congenital Zika virus syndrome in infants from birth to 1–8 months of age, Sao Luis, Brazil, 2015–2016.

Characteristic	No. (%)
Rash in mother during pregnancy, n = 46
First trimester	24 (52.2)
First month	1 (2.2)
Second month	12 (26.1)
Third month	11 (23.9)
Second trimester	10 (21.7)
Fourth month	9 (19.6)
Sixth month	1 (2.2)
No rash	12 (26.1)
Sex, n = 48
M	25 (52.1)
F	23 (47.9)
Gestational age at birth, n = 47
Preterm	4 (8.5)
Term	41 (87.2)
Postterm	2 (4.3)
Head circumference z-score at birth,* n = 45
>–2	6 (13.3)
Microcephaly, <–2	10 (22.2)
Severe microcephaly, <–3	29 (64.5)
Birth length z-score,* n = 3
>–2	21 (56.8)
<–2	11 (29.7)
<–3	5 (13.5)
Birthweight z-score,* n = 46
>–2	37 (80.4)
<–2	8 (17.4)
<–3	1 (2.2)
Age at last visit, mo, n = 48
1	2 (4.2)
2	6 (12.5)
3	7 (14.6)
4	10 (20.8)
5	10 (20.8)
6	7 (14.6)
7	5 (10.4)
8	1 (2.1)
Phenotype, n = 48
Craniofacial disproportion	46 (95.8)
Biparietal depression	40 (83.3)
Prominent occiput	36 (75.0)
Excess nuchal skin	23 (47.9)
Signs and symptoms, n = 48
Irritability	41 (85.4)
Pyramidal/extrapyramidal syndrome	27 (56.3)
Epileptic seizures	24 (50.0)
Dysphagia	7 (14.6)
Congenital clubfoot	5 (10.4)
Arthrogryposis	5 (10.4)
Cleft lip/cleft palate	1 (2.1)
Electroencephalogram findings, n = 27
Abnormal activity, no epileptiform discharges	13 (48.1)
Focal epileptiform discharges	8 (29.6)
Multifocal epileptiform discharges	6 (22.2)
Cranial computed tomography imaging findings, n = 48
Calcifications in the brain parenchyma	44 (91.7)
Malformation of cortical development	42 (87.5)
Ventriculomegaly	37 (77.1)
White matter attenuation	15 (31.3)
Brain stem and cerebellum hypoplasia	6 (12.5)

*Reported as deviations of the raw z-score from the mean measured in SD units.